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Your Height is Based on FGFR3 Gene

The human body contains more than two million genes inside it. Each and every gene is made up of DNA found in Chromosomes. All the genes present in the body are inherited from your parents. And these genes are highly affective on your behavior, lifestyle, health, and fitness. Apart from these, your height is also pretty much based on a gene. This gene is going to be discussed here in detail. 

The gene that is related to your height is the FGFR3 gene. FGFR stands for fibroblast growth factor receptor 3. The gene provides instructions that make a protein called fibroblast growth 3. The protein is inherited from the family chromosomes and plays a key role in the development of several cellular processes. These cellular processes generally include cell growth regulation, division of cells, determining the type of cell, production & formation of blood vessels, healing of a fresh or old wound, and developing the embryo.

Location of FGFR3 Gene

Molecular Location: base pairs 1,793,293 to 1,808,872 on chromosome 4 (Homo sapiens Updated Annotation Release 109.20200228, GRCh38.p13).

Health Conditions Due to its Mutation

When the FGFR3 gene passes through the mutation process, it causes several health conditions. The health conditions related to this genetic change are listed below:

• Achondroplasia: About 99% of the total cases of achondroplasia is caused due to two mutations of the FGFR3 gene. It is a form of short-limbed dwarfism. 
• Crouzon Syndrome: Unlike Achondroplasia, Crouzon Syndrome is caused by the single mutation of the FGR3 gene. Crouzon Syndrome usually causes premature joining of skull bones. 
• Epidermal Nevus: The risk of this genetic condition rises up to 40% if a person’s FGFR3 gene passes through the mutation process. It is a clinical term for a family of skin lesions and is very rare. 
• Muenke Syndrome: similar to others, a single mutation in the FGFR3 gene can cause Muenke Syndrome, which can further cause numerous severe symptoms. 

Other conditions include Lacrimo Syndrome, SADDAN, Thanatophoric Dysplasia, Bladder Cancer, Multiple Myeloma, Genetic Disorders, Hypochondroplasia, and a few cancers. 

Other Names of FGFR3 Gene

Before ending up, let us find out some other names of this gene.

• ACH
• CD333
• FGFR3
• FGR_3 HUMAN
• Fibroblast growth receptor 3
• HGBFR
• JTK4
• Hydroxyary-protein kinase
• Tyrosine kinase JTK4